The Need for Evidence in Humans for the Free Radical Theory of Aging
نویسنده
چکیده
Is oxidative damage of DNA responsible for physiological changes associated with aging? The authors note a positive correlation between the age of human subjects with the level of 8-oxo-7,8-dihydro-2 -deoxyguanosine (8-oxodG) in leukocyte DNA. The levels of urinary 8-oxo-7,8-dihydroguanine and 8-oxodG followed the same pattern of correlation. Age-dependent decline in the concentration of plasma vitamin C was also evident. These interesting observations in humans point towards the need to scrutinize in detail the role of oxidative DNA damage and compromised antioxidant defense systems in age-related physiological disorders. Antioxid. Redox Signal. 9, 143–150. News & Views ANTIOXIDANTS & REDOX SIGNALING Volume 9, Number 1, 2007 © Mary Ann Liebert, Inc. 14351c09.pgs 11/14/06 4:32 PM Page 143
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